This long-used antibiotic has been shown to lead to cancer cell death in a number of laboratory settings and is believed to work against cancer stem cells by inhibiting mitochondrial function.
- Active Clinical Trials
It's available by prescription only and commonly taken preventatively by those traveling to countries with Malaria.
It is also one of the four drugs used by CareOncology to treat cancer.
None currently available
Title: Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy
Summary: In this study, scientists tested the efficacy of Doxycycline against glioblastoma cells in a laboratory setting, and on mice with implanted brain tumors.
- On GB cell lines, Doxycycline inhibited cancer cell growth
- Doxycycline sensitized the cells to chemotherapy
- Mice receiving chemotherapy and Doxycycline exhibited a significant decrease in tumor growth
Title: Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease
Summary: This 2015 study chronicles the number of ways various antibiotics, including Doxycycline, inhibit cancer cell growth, including Glioblastoma.
- They are non-toxic to normal cells
- They warrant further study