Metformin

Metformin is proving to be a useful drug when repurposed for many diseases, including brain cancer. 

And as the importance of maintaining a relatively low and consistent blood-sugar level continues to gain recognition in the medical world, it is now being taken preventatively as an anti-cancer and overall health agent.

  • Resources
  • Active Clinical Trials (2)
  • Studies

The trials do not establish a standard recommended dosage; so, it's something to speak with a doctor about. 

Also, as it is one of the four drugs used by CareOncology to treat cancer, they could be a resource as well. 

Title: Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM

Link: https://clinicaltrials.gov/ct2/show/NCT02780024

Locations:

  • Montreal Neurological Institute - McGill University Health Centre Recruiting

Montréal, Quebec, Canada, H3A 2B4

Contact: Marianna Perna, CCRP,CCRC    514-934-1934 ext 43191    marianna.perna@muhc.mcgill.ca  

Contact: Tatiana Carvalho, CCRP    514-934-1934 ext 43698    tatiana.carvalho@muhc.mcgill.ca  

Principal Investigator: George Shenouda, MD

Sub-Investigator: Bassam Abdulkarim, MD

Sub-Investigator: Scott Owen, MD

Sub-Investigator: Kevin Petrecca, MD

Sub-Investigator: Valerie Panet-Raymond, MD

Sub-Investigator: Luis Souhami, MD

Sub-Investigator: Marie-Christine Guiot, MD

Inclusion criteria: Newly Diagnosed

Treatment Protocol: Patients will take Metformin in conjunction with the standard chemotherapy and radiation protocol

 


 

Title: Bioavailability of Disulfiram and Metformin in Glioblastomas (INSIDE)

Link: https://clinicaltrials.gov/ct2/show/NCT03151772

Locations: 

  • Sahlgrenska University Hospital

Göteborg, Sweden

Contact: Louise Carstam, MD.  46313421000    louise.carstam@vgregion.se

Contact: Asgeir S Jakola, MD, Ph.D. 46313421000    asgeir.jakola@vgregion.se

Inclusion criteria: Newly diagnosed, Surgery Intended

Treatment Protocol: Patients will take either Disulfiram or Metformin pre-operatively in order to determine whether either drug crosses the blood-brain barrier and reaches the tumor.

Title: Metformin as Potential Therapy for High-Grade Glioma

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016983/

Summary: From January 2020, this study reviews the research on the use of Metformin to treat brain cancer to date.

Key takeaways:

  • The authors come to the conclusion that it has a role to play in cancer treatment
  • There is low toxicity and it is usually well-tolerated
  • It appears to increase the effectiveness of both chemotherapy and radiation

 


 

Title: Metformin influences progression in diabetic glioblastoma patients

Link: https://pubmed.ncbi.nlm.nih.gov/26329695/

Summary: This study of diabetic brain cancer patients at a German hospital, 40 of which happened to be diabetic, and 20 of which were on Metformin, compared the outcomes of each patient group.

Key takeaways:

  • Those on Metformin exhibited longer progression-free survival
  • High blood sugar levels were strongly associated with decreased survival rates
  • Metformin usage was correlated with a higher percentage of desired outcomes

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