Metformin is proving to be a useful drug when repurposed for many diseases, including brain cancer.
And as the importance of maintaining a relatively low and consistent blood-sugar level continues to gain recognition in the medical world, it is now being taken preventatively as an anti-cancer and overall health agent.
- Active Clinical Trials (2)
The trials do not establish a standard recommended dosage; so, it's something to speak with a doctor about.
Also, as it is one of the four drugs used by CareOncology to treat cancer, they could be a resource as well.
Title: Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
- Montreal Neurological Institute - McGill University Health Centre Recruiting
Montréal, Quebec, Canada, H3A 2B4
Principal Investigator: George Shenouda, MD
Sub-Investigator: Bassam Abdulkarim, MD
Sub-Investigator: Scott Owen, MD
Sub-Investigator: Kevin Petrecca, MD
Sub-Investigator: Valerie Panet-Raymond, MD
Sub-Investigator: Luis Souhami, MD
Sub-Investigator: Marie-Christine Guiot, MD
Inclusion criteria: Newly Diagnosed
Treatment Protocol: Patients will take Metformin in conjunction with the standard chemotherapy and radiation protocol
Title: Bioavailability of Disulfiram and Metformin in Glioblastomas (INSIDE)
- Sahlgrenska University Hospital
Inclusion criteria: Newly diagnosed, Surgery Intended
Treatment Protocol: Patients will take either Disulfiram or Metformin pre-operatively in order to determine whether either drug crosses the blood-brain barrier and reaches the tumor.
Title: Metformin as Potential Therapy for High-Grade Glioma
Summary: From January 2020, this study reviews the research on the use of Metformin to treat brain cancer to date.
- The authors come to the conclusion that it has a role to play in cancer treatment
- There is low toxicity and it is usually well-tolerated
- It appears to increase the effectiveness of both chemotherapy and radiation
Title: Metformin influences progression in diabetic glioblastoma patients
Summary: This study of diabetic brain cancer patients at a German hospital, 40 of which happened to be diabetic, and 20 of which were on Metformin, compared the outcomes of each patient group.
- Those on Metformin exhibited longer progression-free survival
- High blood sugar levels were strongly associated with decreased survival rates
- Metformin usage was correlated with a higher percentage of desired outcomes