Melatonin supports overall body health and healing in a number of ways.   

It has anti-cancer properties, protects healthy cells from the effects of chemotherapy, lowers the toxicity levels of standard treatments, and helps restore the natural circadian rhythm of the body.

  • Resources
  • Active Clinical Trials
  • Studies

Based on studies, the anti-cancer dosage appears to be 20/mg daily before bed and while that may sound high, it has been consistently well tolerated.

This is a high-quality manufactured brand recommended to patients by Dr. Heather Wright, ND, FABNO:

Vital Nutrients Melatonin 20mg

None currently available

Title: Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone


Summary: To test the efficacy of melatonin in slowing the progression of brain cancer, this randomized study gave 15 patients radiation alone and 15 patients melatonin plus radiation and found that those receiving both treatments had significantly better outcomes.

Key takeaways:

  • Melatonin supplementation led to both longer survival time and disease-free progression
  • Toxicities from radiation and steroids were lower in those receiving melatonin
  • The authors conclude it is a promising area of potential treatment



Title: Role and Therapeutic Potential of Melatonin in the Central Nervous System and Cancers


Summary: From June 2020, this review of studies and trials to date summarizes the current data on Melatonin to better understand how it is being used in the fight against cancer.

Key takeaways:

  • There are studies showing the efficacy of Melatonin as a cancer-fighting agent
  • Melatonin has also been shown to minimize the toxicity of chemotherapy
  • Further study is warranted



Title: Melatonin's Antineoplastic Potential Against Glioblastoma


Summary: From March 2020, this study analyzes the current data on melatonin in trials to date, how it works in combination with the traditional chemotherapy/radiation protocol, and the potential mechanisms by which it leads to cancer cell death.

Key takeaways:

  • It is a promising agent in the fight against cancer cells
  • The cell studies with melatonin and cancer cells are “remarkable”
  • More studies are warranted

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